Gross cystic disease fluid protein 15/GCDFP15

Rb, 1 ml RTU

Artikelnummer:2-GR027-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Breast, breast carcinoma, skin (sweat glands)
Zelluläre Lokalisation:Cytoplasmic
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human GCDFP-15
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Ready-to-use
Reaktivität AK:Human, others not tested.
Synonyme:GCDGP 15, GCDGP-15, Gp17, GPIP4, Gross cystic disease fluid protein 15, Prolactin induced protein, Prolactin inducible protein precursor, SABP, Secretory actin binding protein.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

GCDFP-15 is a glycoprotein that is originally isolated in human breast gross cystic fluid. Approximately 70 % of breast carcinomas stain positive with antibody to GCDFP-15. It is used to differentiate breast carcinoma metastatic to ovary (positive) from primary ovarian carcinoma (negative). It is a marker of apocrine differentiation, including apocrine carcinoma of breast. Colorectal carcinomas, as well as mesotheliomas do not stain with this antibody. Lung adenocarcinoma rarely stains with this antibody.

Literatur

[1] Darb-Esfahani S, von Minckwitz G, Denkert C et al. (2014): Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes. BMC Cancer. 14:546.
[2] Hassan MI, Waheed A, Yadav S et al. (2009): Prolactin inducible protein in cancer, fertility and immunoregulation: structure, function and its clinical implications. Cell Mol Life Sci. 66(3):447-59.

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