Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. GLUT1 is a membrane-associated erythrocyte glucose transport protein that is a major glucose transporter in the mammalian blood-brain barrier. GLUT1 is expressed in many human tissues like colon, lung, stomach, esophagus, and breast. It is overexpressed in malignant cells and in a variety of tumors (breast, pancreas, cervix, endometrium, lung, mesothelium, colon, bladder, thyroid, bone, soft tissues, and oral cavity).