GATA binding factor 3/GATA3

Rb, 1 ml RTU

Artikelnummer:2-GA075-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Breast carcinoma, urothelial carcinoma
Zelluläre Lokalisation:Nuclear
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human GATA-3
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Ready-to-use
Reaktivität AK:Human, others not tested.
Synonyme:GATA 3, GATA3, GATA binding factor 3, GATA binding protein 3, HDR, MGC2346, MGC5199, MGC5445, Trans acting T cell specific transcription factor GATA 3.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

GATA3 is a zinc finger transcription factor that plays an important role in promoting and directing cell proliferation, development, and differentiation. Expression is mainly found in breast carcinoma and urothelial carcinoma. Therefore, this antibody can be used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are possible.

Literatur

[1] Chou J, Provot S and Werb Z (2010): GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol. 222(1):42-9.
[2] Takaku M, Grimm SA and Wade PA (2015): GATA3 in Breast Cancer: Tumor Suppressor or Oncogene? Gene Expr. 16(4):163-8.
[3] Chang A, Amin A, Gabrielson E et al. (2012): Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. Am J Surg Pathol. 36(10):1472-6.

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