Flightless 1

A23, Ms

Technische Daten
Status:Research Use Only (RUO)
Ig Unterklasse:IgG2a
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear, cytoplasmic
Kontrolle:Skeletal muscle
Change(s) made:Complete revision
Synonyme:Fli 1, FLI, Fli1, Flightless 1, Flightless I (Drosophila) homolog, Flightless I homolog, Flightless I homolog (Drosophila), Flightless1, FlightlessI, fliI, FLII_HUMAN, Fliih, FLIL, MGC39265, Protein flightless 1 homolog, Protein flightless-1 homolog
Verfügbar in folgenden Ländern:worldwide

Flightless 1, originally identified as a Drosophila melanogaster mutant, is a member of the gelsolin superfamily with an N-terminal leucine-rich repeat domain and a C-terminal gelsolin-like domain. Through its bipartite domain structure, Fli-1 can bind to numerous structural and signaling proteins and thus regulate cell migration, wound healing, and inflammation. Furthermore, Fli-1 modulates cell proliferation and survival in cancer cells by interacting with transcription factors such as androgen receptor, estrogen receptor (ER), and carbohydrate responsive element-binding protein.