Technische Daten
| Status: | In Vitro Diagnostic Use (IVD) | | Spezies: | Mouse | | Ig Unterklasse: | IgG1/k | | Immunogen: | Ep-CAM/Epithelial Specific Antigen | | Vorbehandlung: | ProTaqs® Antigen Enhancer I (Cat. No. 401602092) | | Zelluläre Lokalisation: | Cytoplasmic | | Kontrolle: | Columnar epithelium, adenocarcinoma | | Change(s) made: | Complete revision | | Synonyme: | Epithelial cell adhesion molecule, TACSTD, tumor-associated calcium signal transducer 1, CD326, cluster of differentiation 326, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP2 | | Verfügbar in folgenden Ländern: | worldwide |
Beschreibung
Ep-CAM, also known as Epithelial Specific Antigen, is a transmembrane glycoprotein involved in cell adhesion in epithelia, in cell signaling, proliferation, differentiation and migration. Expression is found on most normal epithelia, within the cytoplasm of non-squamous epithela and epithelial derived neoplasms.
Ep-CAM is overexpressed in certain carcinomas. Therefore, Ber-EP4 may be a diagnostic marker for various cancers including adenocarcinomas, neuroendocrine tumors, renal cell carcinoma, hepatocellular carcinoma and carcinomas of colon, pancreas and breast. Ber-EP4 is a sensitive marker of basal cell carcinomas.
Literatur
[1] Dasgeb B, Mohammadi TM and Mehregan DR (2013): Use of Ber-EP4 and Epithelial Specific Antigen to Differentiate Clinical Simulators of Basal Cell Carcinoma. Biomark Cancer. 5:7-11.
[2] J Latza U, Niedobitek G, Schwarting R et al. (1990): Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial. Clin Pathol. 43(3):213-9.
[3] Bourroul MSJ, Trindade LL, Nascimento VSD et al. (2018): Solitary plantar basal cell carcinoma. An Bras Dermatol. 93(3):419-421.
[4] Tyagi R, Kaur D, Kaur G et al. (2017): Nodular Cystic Basal Cell Carcinoma of the Trunk: a Diagnostic Dilemma in an Unsuspecting Youth. Iran J Pathol. 12(4):410-412.
[5] Wang B, Li D, Ou X et al. (2014): Diagnostic accuracy of Ber-EP4 for metastatic adenocarcinoma in serous effusions: a meta-analysis. PLoS One. 9(9):e107741.
|
