Technische Daten
Reaktivität AK: | Human, others not tested. | Format AK: | Concentrate | Klon: | Polyclonal | Spezies: | Rabbit | Ig Unterklasse: | IgG | Immunogen: | Synthetic peptide of human ERG C-terminal | Anwendung AK: | IHC(p),IHC(f) | Fixierung: | 1) NOTOXhisto 2) Formalin | Zelluläre Lokalisation: | Nuclear | Kontrolle: | Human prostate adenocarcinoma tissue | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | Synonyme: | ETS related gene | Verfügbar in folgenden Ländern: | world wide | Status: | RUO |
Beschreibung
ERG, also known as ETS related gene, is a member of the ETS family of transcription factors that play important roles in cell development, differentiation, proliferation, apoptosis and tissue remodeling. The antibody labels endothelial cells, lymphocytes, and prostate cancer cells. Overexpression of ERG is associated with prostate cancer. Furthermore, the TMPRSS2-ERG fusion caused by translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer. EWS-ERG, or EWS-Fli-1 fusion, is a characteristic of EwingÕs sarcoma.
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