Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human EGFR
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Cytoplasmic, membranous
Kontrolle:Lymph node metastasis, tonsil, squamous cell carcinoma
Change(s) made:Complete revision
Synonyme:EGFR, ERBB, ERBB1, HER1, mENA, PIG61, Avian erythroblastic leukemia viral (verbb) oncogene homolog, EGF R, EGFR, Epidermal growth factor receptor, erbb 1, Erbb, Erbb1, mENA, Oncogene ERBB, Receptor tyrosine protein kinase ErbB1, Urogastrone, wa2, Wa5
Verfügbar in folgenden Ländern:worldwide

Epidermal growth factor is a growth factor that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. EGFR is a receptor tyrosine kinase activating several signaling cascades. It is ubiquitously expressed and observed in tumors of head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach, and in squamous cell carcinoma. Overexpression of EGFR in tumors indicates poor prognosis. The antibody detects both EGFR phosphorylated on Tyr1068 of the mature human isoform 1 (corresponding to Y1092 from the precursor form P00533-1/p170), and also unphosphorylated EGFR.