E-Cadherin

Rb, 1 ml RTU

Artikelnummer:2-CA003-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide corresponding to residues in the 5th cadherin domain of human E-Cadherin
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous
Kontrolle:Colon, colon cancer
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:anion exchanger protein 3, Arc 1, Cadherin 1, cadherin 1 type 1 E-cadherin, Cadherin1, CAM 120/80, CD 234, CD324, CD324 antigen, CDH1, CDHE, ECAD, Epithelial cadherin, epithelial calcium dependant adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin, CADH1_HUMAN.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

E-cadherin is a transmembrane protein that is important for epithelial cell adhesion. This antibody detects glandular epithelium, adenocarcinomas of the lung gastrointestinal tract and ovary as well as thyroid carcinomas. It has been useful in distinguishing adenocarcinoma from mesothelioma. In combination with p120 or cytokeratin it involves the differentiation of ductal (E-cadherin positive) and lobular (E-cadherin negative) breast carcinoma.

Literatur

[1] Shiozaki H, Tahara H, Oka H et al. (1991) Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol. 139(1):17-23
[2] Heimann R, Lan F, McBride R et al (2000) Separating favorable from unfavorable prognostic markers in breast cancer: the role of E-cadherin. Canc Res. 60(2):298-304
[3] Moll R, Mitze M, Frixen UH et al (1993) Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol. 143(6):1731-42
[4] Gaetje R, Kotzian S, Herrmann G et al (1997) Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E-cadherin. Am J Pathol. 150(2):461-7
[5] Abutaily AS, Addis BJ and Roche WR (2002) Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies. J Clin Pathol. 55(9):662-8.
[6] He DN, Zhu HS, Zhang KH et al (2004) E-cadherin and calretinin as immunocytochemical markers to differentiate malignant from benign serous effusions. World J Gastroenterol. 10(16): 2406-2408.
[7] Han J, Kim MK, Nam SJ et al (2004) E-cadherin and Cytokeratin Subtype Profiling in Effusion Cytology. J Korean Med Sci. 19(6): 826-833.
[8] Acs G, Lawton TJ, Rebbeck TR et al (2001) Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications. Am J Clin Pathol. 115(1):85-98.

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