Desmin

D33, Ms

Artikelnummer:DE074-H
Menge:
Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:Desmin
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Skeletal muscle
Change(s) made:Complete revision
Synonyme:DES, CMD1I, CSM1, CSM2, MFM1, SCPNK
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Desmin is a muscle-specific intermediate filament protein type III and is found in the dense bodies of smooth muscle cells and in the Z-disk of striated muscles. Desmin connects the contractile apparatus to the subsarcolemmal cytoskeleton and organelles like nuclei. It also forms a scaffold around the myofibrillar Z-disk. It is useful in the detection of tumors with myoid origin and to differentiate mesothelioma from carcinoma.

Literatur

[1] Paulin D and Li Z (2004) Desmin: a major intermediate filament protein essential for the structural integrity and function of muscle. Exp Cell Res. 301(1):1-7.
[2] Parham DM, Webber B, Holt H et al. (1991) Immunohistochemical Study of Childhood Rhabdomyosarcomas and Related Neoplasms. Cancer. 67(12):3072-80.

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