Cytokeratin 8/18

TS1/DC10, Ms

Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG1/k, IgG1/k
Immunogen:CK8 & CK18
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Pancreas, prostate, salivary gland
Change(s) made:Complete revision
Synonyme:CK8 & CK18
Verfügbar in folgenden Ländern:worldwide

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratin 8 is a type II keratin and Cytokeratin 18 is a type I keratin. It is the major keratin pair in most simple epithelium including thyroid, female breast, gastrointestinal tract and respiratory tract. CK8 detects most non-squamous epithelial tumors and adenocarcinomas of the breast, ovary, gastrointestinal tract, thyroid, pancreas, bile duct and salivary glands. CK18 recognizes squamous carcinomas. These cytokeratins are absent from keratinizing squamous carcinomas.