Cytokeratin 7

OV-TL 12/30, Ms

Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG1/k
Immunogen:Cytokeratin 7
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Adenocarcinoma of lung, salivary gland
Change(s) made:Complete revision
Synonyme:Keratin type II cytoskeletal 7,CK-7, keratin-7, K7, sarcolectin, SCL, KRT7, K2C7
Verfügbar in folgenden Ländern:worldwide

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells and their neoplasms. Cytokeratin 7 is a type II keratin that is found in most ductal and glandular epithelia including the urinary tract, lung, breast and female genital tract. There is no expression in most gastrointestinal epithelia, prostate, hepatocyte and squamous epithelia, as well as in colon, prostate and squamous carcinomas. Restricted distribution of CK7 makes this antibody a useful marker in a panel with antibody Cytokeratin 20.


[1] Kummar S, Fogarasi M, Canova A et al. (2002): Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br J Cancer. 86(12):1884-7.
[2] Chu P, Wu E and Weiss LM (2000): Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol. 13(9):962-72.