Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells and their neoplasms. Cytokeratin 20 is a type I keratin mainly found in the gastric and intestinal mucosa. Antibody Cytokeratin 20 is useful in the detection of a variety of adenocarcinomas arising from epithelia, such as colorectal carcinomas, transitional-cell and Merkel cell carcinomas, gastric and pancreatic tumors. CK20 is often used in a panel with antibody Cytokeratin 7.

[1] Kummar S, Fogarasi M, Canova A et al. (2002): Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br J Cancer. 86(12):1884-7.
[2] Chu P, Wu E and Weiss LM (2000): Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol. 13(9):962-72.
[3] Moll R, Löwe A, Laufer J and Franke WW (1992): Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol. 140(2):427-47.
[4] Moll R, Schiller DL and Franke WW (1990): Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J Cell Biol. 111(2):567-80.
[5] Wauters CC, Smedts F, Gerrits LG et al. (1995): Keratins 7 and 20 as diagnostic markers of carcinomas metastatic to the ovary. Hum Pathol. 26(8):852-5.