Cyclin D1
Rb, 0.5 ml Conc.
Technische Daten
| Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Kontrolle: | Breast carcinomas, mantle cell lymphoma | | Zelluläre Lokalisation: | Nuclear | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Anwendung AK: | IHC(p),IHC(f) | | Immunogen: | Synthetic peptide of human Cyclin D1 | | Ig Unterklasse: | IgG | | Spezies: | Rabbit | | Klon: | Polyclonal | | Format AK: | Concentrate | | Reaktivität AK: | Human, others not tested. | | Synonyme: | Cyclin D1, CyclinD1, Cyclin-D1, B cell ccl/lymphoma 1, B cell leukemia 1, B-cell CLL/lymphoma 1, B-cell leukemia 1, B-cell lymphoma 1 protein, BCL-1, BCL1, BCL1 oncogene, CCND 1, CCND1, CCND1 protein, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, included, Parathyroid adenomatosis 1, PRAD1. | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
Cyclin D1 plays an important role in control of cell cycle
and cell proliferation by regulating cyclin-dependent
kinases. Cyclin D1 is a proto-oncogen. Overexpression
and nuclear accumulation is associated with various
cancers including breast, colon and prostate cancer,
melanoma and lymphoma. Cyclin D1 may be used to
differentiate mantle cell lymphoma from other B cell
lymphoma.
Literatur
[1] FustŽ NP, Castelblanco E, Felip I et al. (2016):
Characterization of cytoplasmic cyclin D1 as a marker of
invasiveness in cancer. Oncotarget. 7(19): 26979-26991.
[2] Pathak P, Li Y, Gray BA et al. (2017): Synchronous
Occurrence of Chronic Myeloid Leukemia and Mantle Cell
Lymphoma. Case Rep Hematol. 2017: 7815095.
[3] Nœ–ez KG, Gonzalez-Rosario J, Thevenot PT and
Cohen AJ (2017): Cyclin D1 in the Liver: Role of
Noncanonical Signaling in Liver Steatosis and Hormone
Regulation. Ochsner J. 17(1): 56-65.
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