Cyclin D1

Rb, 1 ml RTU

Artikelnummer:2-CY018-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Breast carcinomas, mantle cell lymphoma
Zelluläre Lokalisation:Nuclear
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human Cyclin D1
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Ready-to-use
Reaktivität AK:Human, others not tested.
Synonyme:Cyclin D1, CyclinD1, Cyclin-D1, B cell ccl/lymphoma 1, B cell leukemia 1, B-cell CLL/lymphoma 1, B-cell leukemia 1, B-cell lymphoma 1 protein, BCL-1, BCL1, BCL1 oncogene, CCND 1, CCND1, CCND1 protein, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, included, Parathyroid adenomatosis 1, PRAD1.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Cyclin D1 plays an important role in control of cell cycle
and cell proliferation by regulating cyclin-dependent
kinases. Cyclin D1 is a proto-oncogen. Overexpression
and nuclear accumulation is associated with various
cancers including breast, colon and prostate cancer,
melanoma and lymphoma. Cyclin D1 may be used to
differentiate mantle cell lymphoma from other B cell
lymphoma.

Literatur

[1] FustŽ NP, Castelblanco E, Felip I et al. (2016): Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer. Oncotarget. 7(19): 26979-26991.
[2] Pathak P, Li Y, Gray BA et al. (2017): Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma. Case Rep Hematol. 2017: 7815095.
[3] Nœ–ez KG, Gonzalez-Rosario J, Thevenot PT and Cohen AJ (2017): Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation. Ochsner J. 17(1): 56-65.

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