Technische Daten
| Reaktivität AK: | Human, others not tested. | | Format AK: | Ready-to-use | | Klon: | Polyclonal | | Spezies: | Rabbit | | Ig Unterklasse: | IgG | | Immunogen: | Synthetic peptide of human Claudin 7 protein | | Anwendung AK: | IHC(p),IHC(f) | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Zelluläre Lokalisation: | Membranous | | Kontrolle: | Kidney, renal cell carcinoma | | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Synonyme: | CEPTR L2 antibody
CEPTRL 2 antibody
CEPTRL2 antibody
Claudin 1 antibody
Claudin 7 antibody
Claudin 9 antibody
Claudin-7 antibody
Claudin1 antibody
Claudin7 antibody
Claudin9 antibody
CLD7_HUMAN antibody
CLDN 7 antibody
CLDN-7 antibody
CLDN7 antibody
Clostridium perfringens enterotoxin receptor like 2 antibody
CPETR L2 antibody
CPETRL 2 antibody
CPETRL2 antibody
Hs.84359 antibody | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
The claudin family of epithelial tight junction proteins plays critical roles for cell-cell adhesion and maintenance of cellular polarity. Claudin members are expressed in a tissue specific manner. Claudin 7 expression is localized to the distal nephron epithelium. It has been extensively studied in renal cell carcinoma (RCC) subtypes.
Literatur
[1] Hornsby CD, Cohen C, Amin MB et al. (2007):
Claudin-7 immunohistochemistry in renal tumors: a
candidate marker for chromophobe renal cell carcinoma
identified by gene expression profiling. Arch Pathol Lab
Med. 131(10):1541-6.
[2] Lechpammer M, Resnick MB, Sabo E et al. (2008):
The diagnostic and prognostic utility of claudin expression
in renal cell neoplasms. Mod Pathol. 21(11):1320-9.
[3] Wang K, Xu C, Li W, Ding L (2018): Emerging clinical
significance of claudin-7 in colorectal cancer: a review.
Cancer Manag Res. 10:3741-3752.
[4] Yi X, Wang Y, Yu FS (2000): Corneal epithelial tight
junctions and their response to lipopolysaccharide
challenge. Invest Ophthalmol Vis Sci. 41(13):4093-100.
[5] Reyes JL, Lamas M, Martin D et al. (2002): The renal
segmental distribution of claudins changes with
development. Kidney Int. 62(2):476-87.
[7] Wu Z, Shi J, Song Y et al. (2018): Claudin-7 (CLDN7)
is overexpressed in gastric cancer and promotes gastric
cancer cell proliferation, invasion and maintains
mesenchymal state. Neoplasma. 65(3):349-359.
[8] Lu Z, Kim DH, Fan J et al. (2015): A non-tight junction
function of claudin-7-Interaction with integrin signaling in
suppressing lung cancer cell proliferation and
detachment. Mol Cancer. 14:120.
[9] Constantinou C, Papadopoulos S, Karyda E et al.
(2018): Expression and Clinical Significance of Claudin-7,
PDL-1, PTEN, c-Kit, c-Met, c-Myc, ALK, CK5/6, CK17,
p53, EGFR, Ki67, p63 in Triple-negative Breast Cancer-A
Single Centre Prospective Observational Study. In Vivo.
32(2):303-311.
|
