Claudin 7

Rb, 1 ml Conc.

Artikelnummer:1-CL034-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Claudin 7 protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous
Kontrolle:Kidney, renal cell carcinoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:CEPTR L2 antibody CEPTRL 2 antibody CEPTRL2 antibody Claudin 1 antibody Claudin 7 antibody Claudin 9 antibody Claudin-7 antibody Claudin1 antibody Claudin7 antibody Claudin9 antibody CLD7_HUMAN antibody CLDN 7 antibody CLDN-7 antibody CLDN7 antibody Clostridium perfringens enterotoxin receptor like 2 antibody CPETR L2 antibody CPETRL 2 antibody CPETRL2 antibody Hs.84359 antibody
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

The claudin family of epithelial tight junction proteins plays critical roles for cell-cell adhesion and maintenance of cellular polarity. Claudin members are expressed in a tissue specific manner. Claudin 7 expression is localized to the distal nephron epithelium. It has been extensively studied in renal cell carcinoma (RCC) subtypes.

Literatur

[1] Hornsby CD, Cohen C, Amin MB et al. (2007): Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling. Arch Pathol Lab Med. 131(10):1541-6.
[2] Lechpammer M, Resnick MB, Sabo E et al. (2008): The diagnostic and prognostic utility of claudin expression in renal cell neoplasms. Mod Pathol. 21(11):1320-9.
[3] Wang K, Xu C, Li W, Ding L (2018): Emerging clinical significance of claudin-7 in colorectal cancer: a review. Cancer Manag Res. 10:3741-3752.
[4] Yi X, Wang Y, Yu FS (2000): Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Invest Ophthalmol Vis Sci. 41(13):4093-100.
[5] Reyes JL, Lamas M, Martin D et al. (2002): The renal segmental distribution of claudins changes with development. Kidney Int. 62(2):476-87.
[7] Wu Z, Shi J, Song Y et al. (2018): Claudin-7 (CLDN7) is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, invasion and maintains mesenchymal state. Neoplasma. 65(3):349-359.
[8] Lu Z, Kim DH, Fan J et al. (2015): A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment. Mol Cancer. 14:120.
[9] Constantinou C, Papadopoulos S, Karyda E et al. (2018): Expression and Clinical Significance of Claudin-7, PDL-1, PTEN, c-Kit, c-Met, c-Myc, ALK, CK5/6, CK17, p53, EGFR, Ki67, p63 in Triple-negative Breast Cancer-A Single Centre Prospective Observational Study. In Vivo. 32(2):303-311.

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