Claudin 7


Technische Daten
Status:Research Use Only (RUO)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Claudin 7 protein
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous
Kontrolle:Kidney, renal cell carcinoma
Change(s) made:Complete revision
Synonyme:CEPTR L2 antibody, CEPTRL 2 antibody, CEPTRL2 antibody, Claudin 1 antibody, Claudin 7 antibody, Claudin 9 antibody, Claudin-7 antibody, Claudin1 antibody, Claudin7 antibody, Claudin9 antibody, CLD7_HUMAN antibody, CLDN 7 antibody, CLDN-7 antibody, CLDN7 antibody, Clostridium perfringens enterotoxin receptor like 2 antibody, CPETR L2 antibody, CPETRL 2 antibody, CPETRL2 antibody, Hs.84359 antibody
Verfügbar in folgenden Ländern:worldwide

Claudins are a family of proteins involved in the formation of tight junctions between epithelial cells. They play a role in cell-cell adhesion and maintenance of cellular polarity. The different claudins are expressed in a tissue specific manner. Claudin 7 is localized to the distal nephron epithelium.
Claudin 7 has been extensively studied in renal cell carcinomas, and may be helpful in differential diagnosis of renal cell carcinoma subtypes. Expression has also been observed in different types of malignancies, including colorectal cancer, gastric cancer, breast cancer, ovarian cancer, hepatocellular carcinomas, lung cancer and others.


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[2] Lechpammer M, Resnick MB, Sabo E et al. (2008): The diagnostic and prognostic utility of claudin expression in renal cell neoplasms. Mod Pathol. 21(11):1320-9.
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[7] Wu Z, Shi J, Song Y et al. (2018): Claudin-7 (CLDN7) is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, invasion and maintains mesenchymal state. Neoplasma. 65(3):349-359.
[8] Lu Z, Kim DH, Fan J et al. (2015): A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment. Mol Cancer. 14:120.
[9] Constantinou C, Papadopoulos S, Karyda E et al. (2018): Expression and Clinical Significance of Claudin-7, PDL-1, PTEN, c-Kit, c-Met, c-Myc, ALK, CK5/6, CK17, p53, EGFR, Ki67, p63 in Triple-negative Breast Cancer-A Single Centre Prospective Observational Study. In Vivo. 32(2):303-311.