Caveolin 1

Rb, 0.5 ml Conc.

Artikelnummer:1-CA286-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Caveolin-1
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous, cytoplasmic
Kontrolle:Placenta, mesothelioma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:opamine D3 receptor, Caveolin1, Caveolin 1, 3 dopamine receptor, D, Dopamine receptor D3, DRD, ETM1, FET1, Cav-1, ETM1, CAV 1, CAV1, CAV1_HUMAN.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in receptor-independent endocytosis. Three members of this family exist. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 is most prominently expressed in endothelial, fibrous, and adipose tissue. Caveolins have been implicated in both tumor suppression and oncogenesis. High expression of caveolins leads to inhibition of cancer-related pathways, such as growth factor signaling pathways. However, certain cancer cells that express caveolins have been shown to be more aggressive and metastatic.

Literatur

[1] Amatya VJ, Takeshima Y, Kohno H et al. (2009): Caveolin-1 is a novel immunohistochemical marker to differentiate epithelioid mesothelioma from lung adenocarcinoma. Histopathology. 55(1):10-9.
[2] Hehlgans S, Cordes N (2011): Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance. Am J Cancer Res. 1(4):521-30.
[3] Quann K, Gonzales DM, Mercier I et al. (2013): Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide. Cell Cycle. 12(10):1510-20.
[4] Sloan EK, Ciocca DR, Pouliot N et al. (2009): Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am J Pathol. 174(6):2035-43.
[5] Glenney JR Jr (1992): The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. FEBS Lett. 314(1):45-8.

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