Caveolin 1


Technische Daten
Kontrolle:Placenta, mesothelioma
Zelluläre Lokalisation:Membranous, cytoplasmic
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Immunogen:Synthetic peptide of human Caveolin-1
Ig Unterklasse:IgG
Status:Research Use Only (RUO)
Change(s) made:Complete revision
Synonyme:opamine D3 receptor, Caveolin1, Caveolin 1, 3 dopamine receptor, D, Dopamine receptor D3, DRD, ETM1, FET1, Cav-1, ETM1, CAV 1, CAV1, CAV1_HUMAN.
Verfügbar in folgenden Ländern:worldwide

Caveolin 1 is an integral plasma membrane protein belonging to the Caveoline family. Caveolines are the most common proteins of the caveolae, small indentations of the plasma membrane on the surface of different cell types to regulate molecular processes, such as signal transduction or cell adhesion. The highest expression of caveolin 1 is found in fibroblasts, endothelial cells, type I pneumocytes, epithelial cells and adipocytes.
The antibody caveolin 1 may be useful in the differential diagnosis of epithelioid mesotheliomas from lung adenocarcinomas, especially when incorporated into an antibody panel. While antibodies such as calretinin, podoplanin, Wilms tumor, thrombomodulin and mesothelin are known markers of mesothelioma, the utility of these antibodies is limited due to their low specificity. Caveolin 1 showed high sensitivity and specificity in the differentiation of epithelioid mesothelioma from lung adenocarcinoma.


[1] Amatya VJ, Takeshima Y, Kohno H et al. (2009): Caveolin-1 is a novel immunohistochemical marker to differentiate epithelioid mesothelioma from lung adenocarcinoma. Histopathology. 55(1):10-9.
[2] Hehlgans S, Cordes N (2011): Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance. Am J Cancer Res. 1(4):521-30.
[3] Quann K, Gonzales DM, Mercier I et al. (2013): Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide. Cell Cycle. 12(10):1510-20.
[4] Sloan EK, Ciocca DR, Pouliot N et al. (2009): Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am J Pathol. 174(6):2035-43.
[5] Glenney JR Jr (1992): The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. FEBS Lett. 314(1):45-8.