Catenin beta

14, Ms

Artikelnummer:CA262-H
Menge:
Technische Daten
Kontrolle:Abdomen, fibromatosis of breast, breast carcinoma, prostate, transitional cell carcinoma
Zelluläre Lokalisation:Nuclear, cytoplasmic, membranous
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Immunogen:Beta-catenin
Ig Unterklasse:IgG1
Spezies:Mouse
Status:In Vitro Diagnostic Use (IVD)
Change(s) made:Complete revision
Synonyme:Cadherin associated protein, CTNNB1, FLJ25606, CATNB
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Catenin beta plays an important role in the Wnt signaling pathway and is essential for cell contacts. It has a major impact on development, cell proliferation and differentiation. A mutation in the gene leads to nuclear accumulation, which has been demonstrated in fibromatosis of the breast and abdomen.

Literatur

[1] Li C, Bapat B and Alman BA (1998) Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). Am J Pathol. 153(3):709-14.
[2] Ng TL, Gown AM, Barry TS et al. (2005) Nuclear beta-catenin in mesenchymal tumors. Mod Pathol. 18(1):68-74.
[3] McCrea PD, Brieher WM and Gumbiner BM (1993) Induction of a secondary body axis in Xenopus by antibodies to beta-catenin. J Cell Biol. 123(2):477-84.
[4] Knudsen KA, Wheelock MJ. (1992) Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J Cell Biol. 118(3):671-9.
[5] Alman BA, Li C, Pajerski ME, Diaz-Cano S and Wolfe HJ et al. (1997) Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am J Pathol. 151(2):329-34.

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