Carcinoembryonic antigen/CD66e
Rb, 0.5 ml Conc.
Technische Daten
| Reaktivität AK: | Human, others not tested. | | Format AK: | Concentrate | | Klon: | Polyclonal | | Spezies: | Rabbit | | Ig Unterklasse: | IgG | | Immunogen: | CEA | | Anwendung AK: | IHC(p),IHC(f) | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Zelluläre Lokalisation: | Cytoplasmic | | Kontrolle: | Colon, lung, stomach, breast, associated adenocarcinomas | | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Synonyme: | Carcinoembryonic antigen, Carcinoembryonic antigen related cell adhesion molecule 5, CD66e, CEA, CEACAM5, DKFZp781M2392, Meconium antigen 100, OTTHUMP00000199032, OTTHUMP00000199033, OTTHUMP00000199034 | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion and is produced during fetal development. It is present in the epithelia of various tissues. This antibody is useful to assist in the distinction between adenocarcinoma and mesotheliomas, along with other markers such as calretinin, CK 5/6, D2-40, HBME-1, Napsin A, MOC-31, and Ber-EP4. It detects adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary and endocervix.
Literatur
[1] Taheri M, Saragovi U, Fuks A et al. (2000) Self
recognition in the Ig superfamily. Identification of precise
subdomains in carcinoembryonic antigen required for
intercellular adhesion. J Biol Chem. 275(35):26935-43.
[2] Zheng C, Feng J, Lu D et al. (2011) A novel anti-
CEACAM5 monoclonal antibody, CC4, suppresses
colorectal tumor growth and enhances NK cells-mediated
tumor immunity. PLoS One. 6(6):e21146.
[3] Weichselbaumer M, Willmann M, Reifinger M et al.
(2011) Phylogenetic discordance of human and canine
carcinoembryonic antigen (CEA, CEACAM) families, but
striking identity of the CEA receptors will impact
comparative oncology studies. PLoS Curr. 3:RRN1223.
[4] Morrison C, Marsh W Jr and Frankel WL (2002) A
comparison of CD10 to pCEA, MOC-31, and hepatocyte
for the distinction of malignant tumors in the liver. Mod
Pathol. 15(12):1279-87.
[5] Ko EC, Jhala NC, Shultz JJ et al. (2001) Use of a
panel of markers in the differential diagnosis of
adenocarcinoma and reactive mesothelial cells in fluid
cytology. Am J Clin Pathol. 116(5):709-15.
[6] Fernandes LC, Kim SB, Saad SS et al. (2006) Value
of carcinoembryonic antigen and cytokeratins for the
detection of recurrent disease following curative resection
of colorectal cancer. World J Gastroenterol. 12(24):3891-
4.
[7] Duffy MJ (2001) Carcinoembryonic antigen as a
marker for colorectal cancer: is it clinically useful? Clin
Chem. 47(4):624-30.
[8] Gold P and Freedman SO (1965) Specific
carcinoembryonic antigens of the human digestive
system. J Exp Med. 122(3):467-81.
[9] Röcken C, et al.: Arch Pathol Lab Med. 2000;124(11):1704-6.
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