Carcinoembryonic antigen/CD66e

Rb, 1 ml RTU

Artikelnummer:2-CA174-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:CEA
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Colon, lung, stomach, breast, associated adenocarcinomas
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:Carcinoembryonic antigen, Carcinoembryonic antigen related cell adhesion molecule 5, CD66e, CEA, CEACAM5, DKFZp781M2392, Meconium antigen 100, OTTHUMP00000199032, OTTHUMP00000199033, OTTHUMP00000199034
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion and is produced during fetal development. It is present in the epithelia of various tissues. This antibody is useful to assist in the distinction between adenocarcinoma and mesotheliomas, along with other markers such as calretinin, CK 5/6, D2-40, HBME-1, Napsin A, MOC-31, and Ber-EP4. It detects adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary and endocervix.

Literatur

[1] Taheri M, Saragovi U, Fuks A et al. (2000) Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion. J Biol Chem. 275(35):26935-43.
[2] Zheng C, Feng J, Lu D et al. (2011) A novel anti- CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity. PLoS One. 6(6):e21146.
[3] Weichselbaumer M, Willmann M, Reifinger M et al. (2011) Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies. PLoS Curr. 3:RRN1223.
[4] Morrison C, Marsh W Jr and Frankel WL (2002) A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver. Mod Pathol. 15(12):1279-87.
[5] Ko EC, Jhala NC, Shultz JJ et al. (2001) Use of a panel of markers in the differential diagnosis of adenocarcinoma and reactive mesothelial cells in fluid cytology. Am J Clin Pathol. 116(5):709-15.
[6] Fernandes LC, Kim SB, Saad SS et al. (2006) Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer. World J Gastroenterol. 12(24):3891- 4.
[7] Duffy MJ (2001) Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem. 47(4):624-30.
[8] Gold P and Freedman SO (1965) Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 122(3):467-81.
[9] Röcken C, et al.: Arch Pathol Lab Med. 2000;124(11):1704-6.

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