Caldesmon

Rb

Artikelnummer:CA090-H
Menge:
Technische Daten
Kontrolle:Smooth muscle from bowel, esophagus, uterus
Zelluläre Lokalisation:Cytoplasmic
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Immunogen:Synthetic phospho-peptide of human Caldesmon
Ig Unterklasse:IgG
Spezies:Rabbit
Status:In Vitro Diagnostic Use (IVD)
Change(s) made:Complete revision
Synonyme:CAD, CALD 1, CALD1, Caldesmon 1, Caldesmon 1 Isoform 1, Caldesmon 1 Isoform 2, Caldesmon 1 Isoform 3, Caldesmon 1 Isoform 4, Caldesmon 1 Isoform 5, Caldesmon1, CDM, H CAD, HCAD, L CAD, LCAD, MGC21352, NAG22.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Caldesmon is a regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin. It is found in smooth muscle and other tissues. Caldesmon is useful to distinguish smooth muscle and it is more specific than desmin and muscle specific actin. Caldesmon antibody is a marker to identify epitheloid mesothelioma and it can be used to differentiate uterus leiomyoma from endometrial stroma tumor.

Literatur

[1] Sobue K, Muramoto Y, Fujita M et al. (1981) Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin. Proc Natl Acad Sci U S A. 78(9): 5652Ð5655.
[2] Kakiuchi R, Inui M, Morimoto K et al (1883) Caldesmon, a calmodulin-binding, F actin-interacting protein, is present in aorta, uterus and platelets.. FEBS Lett. 154(2):351-6.
[3] Watson MH, Kuhn AE, Novy RE et al (1990) Caldesmon-binding sites on tropomyosin. J Biol Chem. 265(31):18860-6.
[4] Chalovich JM, Chen YD, Dudek R et al (1995) Kinetics of binding of caldesmon to actin. J Biol Chem. 270(17):9911-6.
[5] Wang CL (2008) Caldesmon and the regulation of cytoskeletal functions. Adv Exp Med Biol. 644:250-72.
[6] Watanabe K, Kusakabe T, Hoshi N,et al (1999) h-Caldesmon in leiomyosarcoma and tumors with smooth muscle celllike differentiation: its specific expression in the smooth muscle cell tumor. Hum Pathol. 30:392-6.

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