Caldesmon

Rb, 1 ml RTU

Artikelnummer:2-CA090-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic phospho-peptide surrounding Ser789 of human Caldesmon
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Smooth muscle from bowel, esophagus, uterus
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:CAD, CALD 1, CALD1, Caldesmon 1, Caldesmon 1 Isoform 1, Caldesmon 1 Isoform 2, Caldesmon 1 Isoform 3, Caldesmon 1 Isoform 4, Caldesmon 1 Isoform 5, Caldesmon1, CDM, H CAD, HCAD, L CAD, LCAD, MGC21352, NAG22.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Caldesmon is a calmodulin-binding protein that tonically inhibits ATPase activity of myosin in smooth muscle. This antibody reacts with caldesmon, which is found in smooth muscle and other tissues that interact with actin, myosin, tropomyosin and calmodulin. It labels tumors of smooth muscle, myofibroblasts and myoepithel as well as epithelioid mesothelioma and serous papillary carcinoma.

Literatur

[1] Sobue K, Muramoto Y, Fujita M et al. (1981) Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin. Proc Natl Acad Sci U S A. 78(9): 5652-5655.
[2] Kakiuchi R, Inui M, Morimoto K et al (1883) Caldesmon, a calmodulin-binding, F actin-interacting protein, is present in aorta, uterus and platelets.. FEBS Lett. 154(2):351-6.
[3] Watson MH, Kuhn AE, Novy RE et al (1990) Caldesmon-binding sites on tropomyosin. J Biol Chem. 265(31):18860-6.
[4] Chalovich JM, Chen YD, Dudek R et al (1995) Kinetics of binding of caldesmon to actin. J Biol Chem. 270(17):9911-6.
[5] Wang CL (2008) Caldesmon and the regulation of cytoskeletal functions. Adv Exp Med Biol. 644:250-72.
[6] Watanabe K, Kusakabe T, Hoshi N,et al (1999) h- Caldesmon in leiomyosarcoma and tumors with smooth muscle celllike differentiation: its specific expression in the smooth muscle cell tumor. Hum Pathol. 30:392-6.

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