Technische Daten
| Reaktivität AK: | Human, others not tested. | | Format AK: | Ready-to-use | | Klon: | Polyclonal | | Spezies: | Rabbit | | Ig Unterklasse: | IgG | | Immunogen: | Synthetic phospho-peptide surrounding Ser789 of human Caldesmon | | Anwendung AK: | IHC(p),IHC(f) | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Zelluläre Lokalisation: | Cytoplasmic | | Kontrolle: | Smooth muscle from bowel, esophagus, uterus | | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Synonyme: | CAD, CALD 1, CALD1, Caldesmon 1, Caldesmon 1 Isoform 1, Caldesmon 1 Isoform 2, Caldesmon 1 Isoform 3, Caldesmon 1 Isoform 4, Caldesmon 1 Isoform 5, Caldesmon1, CDM, H CAD, HCAD, L CAD, LCAD, MGC21352, NAG22. | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
Caldesmon is a calmodulin-binding protein that tonically inhibits ATPase activity of myosin in smooth muscle. This antibody reacts with caldesmon, which is found in smooth muscle and other tissues that interact with actin, myosin, tropomyosin and calmodulin. It labels tumors of smooth muscle, myofibroblasts and myoepithel as well as epithelioid mesothelioma and serous papillary carcinoma.
Literatur
[1] Sobue K, Muramoto Y, Fujita M et al. (1981)
Purification of a calmodulin-binding protein from chicken
gizzard that interacts with F-actin. Proc Natl Acad Sci U S
A. 78(9): 5652-5655.
[2] Kakiuchi R, Inui M, Morimoto K et al (1883)
Caldesmon, a calmodulin-binding, F actin-interacting
protein, is present in aorta, uterus and platelets.. FEBS
Lett. 154(2):351-6.
[3] Watson MH, Kuhn AE, Novy RE et al (1990)
Caldesmon-binding sites on tropomyosin. J Biol Chem.
265(31):18860-6.
[4] Chalovich JM, Chen YD, Dudek R et al (1995) Kinetics
of binding of caldesmon to actin. J Biol Chem.
270(17):9911-6.
[5] Wang CL (2008) Caldesmon and the regulation of
cytoskeletal functions. Adv Exp Med Biol. 644:250-72.
[6] Watanabe K, Kusakabe T, Hoshi N,et al (1999) h-
Caldesmon in leiomyosarcoma and tumors with smooth
muscle celllike differentiation: its specific expression in
the smooth muscle cell tumor. Hum Pathol. 30:392-6.
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