CEA

CEA31, Ms

Artikelnummer:CA175-H
Menge:
Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Spezies:Mouse
Ig Unterklasse:IgG1
Immunogen:CEA
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear, membranous
Kontrolle:Adenocarcinoma of colon, normal colon
Change(s) made:Complete revision
Synonyme:Carcinoembryonic antigen, Carcinoembryonic antigen related cell adhesion molecule 5, CD66e, CEA, CEACAM5, DKFZp781M2392, Meconium antigen 100, OTTHUMP00000199032, OTTHUMP00000199033, OTTHUMP00000199034
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Carcinoembryonic Antigen, also known as CD66e, is a cell surface protein and regulates differentiation and anoikis, tissue architecture, intercellular adhesion and other processes. CEA is a widely used tumor marker and has been found expressed in carcinomas from the gastrointestinal tract especially colorectal cancer and many types of epithelial tumors. The antibody is used as a tool to differentiate lung adenocarcinoma (positive) from mesothelioma (negative) and is also helpful in monitoring tumor progression.

Literatur

[1] Taheri M, Saragovi U, Fuks A et al. (2000) Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion. J Biol Chem. 275(35):26935-43.
[2] Zheng C, Feng J, Lu D et al. (2011) A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity. PLoS One. 6(6):e21146.
[3] Weichselbaumer M, Willmann M, Reifinger M et al. (2011) Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies. PLoS Curr. 3:RRN1223.
[4] Morrison C, Marsh W Jr and Frankel WL (2002) A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver. Mod Pathol. 15(12):1279-87.
[5] Ko EC, Jhala NC, Shultz JJ et al. (2001) Use of a panel of markers in the differential diagnosis of adenocarcinoma and reactive mesothelial cells in fluid cytology. Am J Clin Pathol. 116(5):709-15.
[6] Fernandes LC, Kim SB, Saad SS et al. (2006) Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer. World J Gastroenterol. 12(24):3891-4.
[7] Duffy MJ (2001) Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem. 47(4):624-30.
[8] Gold P and Freedman SO (1965) Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 122(3):467-81.

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