Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human CDX-2
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Nuclear
Kontrolle:Gastric adenocarcinoma, colon, colon adenocarcinoma
Change(s) made:Complete revision
Synonyme:cau-dal-related homeobox transcription factor 2, Caudal type homeo box 2, Caudal type homeobox protein 2, caudal type homeobox transcription factor 2, CDX 2, CDX 3, CDX3, Homeobox protein CDX-2, Homeobox protein CDX2.
Verfügbar in folgenden Ländern:worldwide

CDX2, also known as caudal-related homeodomain protein 2, is a transcription factor expressed in intestine, but not in stomach and esophagus. CDX2 may play an important role in proliferation and differentiation of intestinal epithelial cells. Antibody CDX2 may be useful in detection of colorectal carcinoma with reduced or absent expression. On the other hand CDX2 is expressed in gastric intestinal metaplasia, dysplasia and carcinoma, as well as in acute myeloid leukemia.


[1] Scholl C, Bansal D, Döhner K et al. (2007): The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest. 117(4): 1037-1048.
[2] Liu Q, Teh M, Ito K et al. (2007): CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Mod Pathol. 20(12):1286-97.