CD99

Rb, 0.5 ml Conc.

Artikelnummer:1-CD293-05
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Ependyma, Ewing’s Sarcoma, pancreas
Zelluläre Lokalisation:Membranous
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human CD99 C-terminal
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Concentrate
Reaktivität AK:Human, others not tested.
Synonyme:T-cell surface glycoprotein E, T cell surface glycoprotein E2 precursor, 12E7, Antigen identified by monoclonal 12E7 Y homolog, Antigen identified by monoclonal antibodies 12E7 F21 and O13, CD 99, CD99 antigen, CD99 molecule, CD99X, E2 antigen, Ewing Sarcoma, MIC 2, MIC 2X, MIC 2Y, MIC2, MIC2X, MIC2Y, Monoclonal antibody 12E7, MSK5X, Protein MIC2, Surface antigen MIC2.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CD99 (Cluster of Differentation 99) is a transmembrane glycoprotein, that is involved in T-cell adhesion, leukocyte migration and differentiation of primitive neuroectodermal cells. It is expressed on all leukocytes but highest on thymocytes. This antibody detects lymphocyte, ovarian granulosa cells, pancreatic islet cells, sertoli cells, CNS ependymal cells and endothelial cells. It is a useful marker for Ewing's sarcoma, sex cord-stromal tumor, endocrine tumor of pancreas and a subset of other
tumors including lymphoblastic lymphoma, breast carcinoma and other malignancies.

Literatur

[1] Gelin C, Aubrit F, Phalipon A et al. (1989) The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product. EMBO J. 8(11): 3253-3259.
[2] Fellinger EJ, Garin-Chesa P, Triche TJ A et al. (1991) Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2. Am J Pathol. 139(2): 317- 325.
[3] Lee EJ, Lee HG, Park SH et al. (2003) CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells. Exp Mol Med. 35(5):438-47.

Kontakt