Technische Daten
| Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Kontrolle: | Tonsil, lymph node | | Zelluläre Lokalisation: | Membranous | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Anwendung AK: | IHC(p),IHC(f) | | Immunogen: | Synthetic peptide of human CD8 alpha chain | | Ig Unterklasse: | IgG | | Spezies: | Rabbit | | Klon: | Polyclonal | | Format AK: | Ready-to-use | | Reaktivität AK: | Human, others not tested. | | Synonyme: | CD 8a, CD8 alpha chain, CD8, CD8 antigen alpha chain, CD8 antigen alpha polypeptide, CD8 antigen alpha polypeptide (p32), CD8a, CD8a antigen, CD8a molecule, CD8A_HUMAN, Leu 2, Leu2, Leu2 T lymphocyte antigen, MAL, OKT8 T cell antigen, OTTHUMP00000160760, OTTHUMP00000160764, OTTHUMP00000203528, OTTHUMP00000203721, p32, T cell antigen Leu2, T cell co receptor, T cell coreceptor, T cell surface glycoprotein CD8 alpha chain, T lymphocyte differentiation antigen T8/Leu 2, T lymphocyte differentiation antigen T8/Leu2, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, T8 T cell antigen. | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
CD8 (Cluster of Differentiation 8) is a transmembrane glycoprotein that functions as a co-receptor for T-cell receptor (TCR) and therefore binds to MHC molecules. There are existing two isoforms (alpha and beta). This antibody is a T-cell marker that detects cytotoxic/suppressor cells of blood lymphocytes, NK cells and most thymocytes. It is helpful in differentiation of reactive and neoplastic T-cells.
Literatur
[1] Chiba T, Ohtani H, Mizoi T et al. (2004): Intraepithelial
CD8+ T-cell-count becomes a prognostic factor after a
longer follow-up period in human colorectal carcinoma:
possible association with suppression of micrometastasis.
Br J Cancer. 91(9):1711-7.
[2] Sato E, Olson SH, Ahn J et al. (2005): Intraepithelial
CD8+ tumor-infiltrating lymphocytes and a high
CD8+/regulatory T cell ratio are associated with favorable
prognosis in ovarian cancer. Proc Natl Acad Sci U S A.
102(51):18538-43.
[3] Gupta N, Kumar S, Singh G and Basu A (2015): Adult
T cell large granular lymphocytic leukemia. Med J Armed
Forces India. 71(1):272-5.
[4] Bhaker P, Das A, Rajwanshi A et al. (2015): Precursor
T-lymphoblastic lymphoma: Speedy diagnosis in FNA and
effusion cytology by morphology, immunochemistry, and
flow cytometry. Cancer Cytopathol. 123(9):557-65.
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