Technische Daten
| Status: | In Vitro Diagnostic Use (IVD) | | Spezies: | Mouse | | Ig Unterklasse: | IgG1/k | | Immunogen: | CD8 | | Vorbehandlung: | ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392) | | Zelluläre Lokalisation: | Membranous | | Kontrolle: | Tonsil, lymph node | | Change(s) made: | Complete revision | | Synonyme: | T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, MAL, T-cell surface glycoprotein CD8 beta chain, CD8b | | Verfügbar in folgenden Ländern: | worldwide |
Beschreibung
CD8 is a transmembrane glycoprotein and co-receptor that functions together with T cell receptor (TCR) in adaptive immune response. CD8 is mainly expressed on cytotoxic T cells as well as natural killer cells, cortical thymocytes and dendritic cells.
Furthermore, CD8 is expressed in T cell LGL leukemia and together with CD4 in some T lymphoblastic lymphoma. CD8 can be detected in colorectal carcinoma and ovarian, renal, hepatocellular and esophageal tumors.
Literatur
[1] Chiba T, Ohtani H, Mizoi T et al. (2004): Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis. Br J Cancer. 91(9):1711-7.
[2] Sato E, Olson SH, Ahn J et al. (2005): Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 102(51):18538-43.
[3] Gupta N, Kumar S, Singh G and Basu A (2015): Adult T cell large granular lymphocytic leukemia. Med J Armed Forces India. 71(1):272-5.
[4] Bhaker P, Das A, Rajwanshi A et al. (2015): Precursor T-lymphoblastic lymphoma: Speedy diagnosis in FNA and effusion cytology by morphology, immunochemistry, and flow cytometry. Cancer Cytopathol. 123(9):557-65.
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