CD8

C8/144B, Ms, 7 ml RTU

Artikelnummer:2-CD039-13
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:C8/144B
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:CD8
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Tonsil, lymph node
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Membranous
Synonyme:T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, MAL, T-cell surface glycoprotein CD8 beta chain, CD8b
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

CD8 (Cluster of Differentiation 8) is a transmembrane glycoprotein that functions as a co-receptor for T-cell receptor (TCR) and therefore binds to MHC molecules. There are existing two isoforms (alpha and beta). This antibody is a T-cell marker that detects cytotoxic/suppressor cells of blood lymphocytes, NK cells and most thymocytes. It is helpful in differentiation of reactive and neoplastic T-cells.

Literatur

[1] Chiba T, Ohtani H, Mizoi T et al. (2004): Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis. Br J Cancer. 91(9):1711-7.
[2] Sato E, Olson SH, Ahn J et al. (2005): Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 102(51):18538-43.
[3] Gupta N, Kumar S, Singh G and Basu A (2015): Adult T cell large granular lymphocytic leukemia. Med J Armed Forces India. 71(1):272-5.
[4] Bhaker P, Das A, Rajwanshi A et al. (2015): Precursor T-lymphoblastic lymphoma: Speedy diagnosis in FNA and effusion cytology by morphology, immunochemistry, and flow cytometry. Cancer Cytopathol. 123(9):557-65.

Kontakt