CD8

C8/144B, Ms

Artikelnummer:CD039-H
Menge:
Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:CD8
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous
Kontrolle:Tonsil, lymph node
Change(s) made:Complete revision
Synonyme:T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, MAL, T-cell surface glycoprotein CD8 beta chain, CD8b
Verfügbar in folgenden Ländern:worldwide
Beschreibung

CD8 is a transmembrane glycoprotein and co-receptor that functions together with T cell receptor (TCR) in adaptive immune response. CD8 is mainly expressed on cytotoxic T cells as well as natural killer cells, cortical thymocytes and dendritic cells.
Furthermore, CD8 is expressed in T cell LGL leukemia and together with CD4 in some T lymphoblastic lymphoma. CD8 can be detected in colorectal carcinoma and ovarian, renal, hepatocellular and esophageal tumors.

Literatur

[1] Chiba T, Ohtani H, Mizoi T et al. (2004): Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis. Br J Cancer. 91(9):1711-7.
[2] Sato E, Olson SH, Ahn J et al. (2005): Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 102(51):18538-43.
[3] Gupta N, Kumar S, Singh G and Basu A (2015): Adult T cell large granular lymphocytic leukemia. Med J Armed Forces India. 71(1):272-5.
[4] Bhaker P, Das A, Rajwanshi A et al. (2015): Precursor T-lymphoblastic lymphoma: Speedy diagnosis in FNA and effusion cytology by morphology, immunochemistry, and flow cytometry. Cancer Cytopathol. 123(9):557-65.

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