JCB117, Ms

Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG1/k
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous
Kontrolle:Tonsil, lymph node
Change(s) made:Complete revision
Synonyme:Immunoglobulin-associated alpha, IGA, mb-1
Verfügbar in folgenden Ländern:worldwide

CD79a (mb-1) is an integral membrane protein expressed early in B cell maturation and next to CD75b (B29) one of two polypeptide chains of the CD79 molecule. The dimer of CD79a/b has the function to transmit signals to the B cell receptor signaling complex into the cell for induction of B cell activation. The CD79a antibody is used as a marker for identification of normal and neoplastic B lymphocytes.


[1] Mason DY, Cordell JL, Brown MH et al. (1995) CD79a: A Novel Marker for B-Cell Neoplasms in Routinely Processed. Blood 86(4):1453-9.
[2] Luger D, Yang Y, Raviv A et al. (2013) Expression of the B-Cell Receptor Component CD79a on Immature Myeloid Cells Contributes to Their Tumor Promoting Effects. PLoS One 16;8(10):e76115.