CD68

Kp-1, Ms, 1 ml RTU

Artikelnummer:2-CD246-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Kp-1
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:CD68
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Tonsil, lymph node
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:CD 68, CD68 antigen, CD68 molecule, DKFZp686M18236, GP110, Macrophage antigen CD68 (microsialin), macrosialin, SCARD1, Scavenger receptor class D member 1.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CD68 (Cluster of Differentiation 68) is a glycoprotein which binds to low density lipoprotein. It is expressed on monocytes, macrophages, Kupffer cells, osteoclasts, granulocytes and their precursors. This antibody detects myelomonocytic and histiocytic tumors and it may help to distinguish malignant fibrous histiocytoma from other pleomorphic sarcomas.

Literatur

[1] Holness CL and Simmons DL (1993): Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood. 81(6):1607-13.
[2] Warnke RA, Pulford KA, Pallesen G et al. (1989): Diagnosis of myelomonocytic and macrophage neoplasms in routinely processed tissue biopsies with monoclonal antibody KP1. Am J Pathol. 135(6):1089-95.
[3] Pulford KA, Rigney EM, Micklem KJ et al. (1989): KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol. 42(4):414-21.
[4] Gottfried E, Kunz-Schughart LA, Weber A et al. (2008): Expression of CD68 in non-myeloid cell types. Scand J Immunol. 67(5):453-63.
[5] Athanasou NA, Puddle B, Quinn J and Woods CG (1991): Use of monoclonal antibodies to recognise osteoclasts in routinely processed bone biopsy specimens. J Clin Pathol. 44(8):664-6.

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