CD68

Kp-1, Ms

Artikelnummer:CD246-H
Menge:
Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:CD68
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Tonsil, lymph node
Change(s) made:Complete revision
Synonyme:CD 68, CD68 antigen, CD68 molecule, DKFZp686M18236, GP110, Macrophage antigen CD68 (microsialin), macrosialin, SCARD1, Scavenger receptor class D member 1.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

CD68 (Cluster of Differentiation 68) is a transmembrane glycoprotein which is highly glycosylated in its extracellular domain and has a molecular weight of 110 kDa. It is found in the cytoplasmic granules of a number of different blood cells and myocytes and is considered to be a marker for cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, osteoclasts and their precursors.
The antibody recognizes myelomonocytic and histiocytic tumors and may help distinguish malignant fibrous histiocytomas from other pleomorphic sarcomas.

Literatur

[1] Holness CL and Simmons DL (1993): Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood. 81(6):1607-13.
[2] Warnke RA, Pulford KA, Pallesen G et al. (1989): Diagnosis of myelomonocytic and macrophage neoplasms in routinely processed tissue biopsies with monoclonal antibody KP1. Am J Pathol. 135(6):1089-95.
[3] Pulford KA, Rigney EM, Micklem KJ et al. (1989): KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol. 42(4):414-21.
[4] Gottfried E, Kunz-Schughart LA, Weber A et al. (2008): Expression of CD68 in non-myeloid cell types. Scand J Immunol. 67(5):453-63.
[5] Athanasou NA, Puddle B, Quinn J and Woods CG (1991): Use of monoclonal antibodies to recognise osteoclasts in routinely processed bone biopsy specimens. J Clin Pathol. 44(8):664-6.

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