CD5

4C7, Ms, 0.2 ml Conc.

Artikelnummer:1-CD028-03
Menge:
Technische Daten
Lagerung AK:Aliquot and store at - 20 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Tonsil, lymph node
Zelluläre Lokalisation:Membranous
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:CD5
Ig Unterklasse:IgG/k
Spezies:Mouse
Klon:4C7
Format AK:Concentrate
Reaktivität AK:Human, others not tested.
Synonyme:Lymphocyte antigen T1, Leu-1
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

CD5 (Cluster of Differentiation 5) is a transmembrane glykoprotein and was used as a T-cell marker until antibody CD3 was developed. This antibody recognizes different T-lymphocytes, mantle zone lymphocytes and a few B-lymphocytes. It detects T-cell malignancies, B-cell chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), mantle cell lymphoma and thymic carcinoma.

Literatur

[1] Bashford-Rogers RJM, Palser AL, Hodkinson C et al. (2017): Dynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones. Exp Hematol. 46:31-7.
[2] Hoeller S, Zhou Y, Kanagal-Shamanna R et al. (2013): Composite Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Clinicopathologic and Molecular Study. Hum Pathol. 44(1):110-21.
[3] Knowles DM (1989): Immunophenotypic and antigen receptor gene rearrangement analysis in T cell neoplasia. Am J Pathol. 134(4):761-85.

Kontakt