CD57

NK-1, Ms

Artikelnummer:CD232-H
Menge:
Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Spezies:Mouse
Ig Unterklasse:IgM/k
Immunogen:CD57
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous
Kontrolle:Tonsil, lymph node
Change(s) made:Complete revision
Synonyme:Human natural killer-1, HNK1, LEU7, B3GAT1, GLCATP, GLCUATP, NK-1
Verfügbar in folgenden Ländern:worldwide
Beschreibung

CD57 (Cluster of Differentiation 57) is an adhesion molecule on cell surfaces. The epitope is expressed predominantly on natural killer cells (NK cells) and in a subgroup of T cells, and is most frequently found in the germinal centers of lymph nodes, tonsils and spleen.
The antibody detects NK cells and follicular central cell lymphomas, which often contain many NK cells. CD57 reacts with neuroendocrine cells and their derived tumors, and is a marker for a variety of cell types in non-lymphoid tissues, including neurofibromas, ganglioneuromas and prostate cancers. The number of circulating CD57-positive cells increases in the blood of patients who have recently undergone organ or tissue transplantation, especially of the bone marrow, and of patients with HIV.

Literatur

[1] Ritchie AW, James K, Micklem HS (1983): The distribution and possible significance of cells identified in human lymphoid tissue by the monoclonal antibody HNK-1. Clin Exp Immunol. 51(3):439-47.
[2] Abo T, Miller CA, Gartland GL and Balch CM (1983): Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life. J Exp Med. 157(1):273-84.
[3] Abo T and Balch CM (1981): A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol. 127(3):1024-9.
[4] Nielsen CM, White MJ, Goodier MR and Riley EM (2013): Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease. Front Immunol. 4:422.

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