CD57

NK-1, Ms, 0.5 ml Conc.

Artikelnummer:1-CD232-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:NK-1
Spezies:Mouse
Ig Unterklasse:IgM/k
Immunogen:CD57
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous
Kontrolle:Tonsil, lymph node
Lagerung AK:Aliquot and store at - 20 °C. Do not use after expiration date indicated on the vial.
Synonyme:Human natural killer-1, HNK1, LEU7, B3GAT1, GLCATP, GLCUATP, NK-1
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CD57 (Cluster of Differentiation 57) is an adhesion molecule with a carbohydrate epitope. This antibody detects a subset of lymphocytes known as natural killer (NK) cells and follicular center cell lymphomas which often contain many NK cells. It reacts with neuroendocrine cells and their derived tumors (carcinoid tumors, medulloblastoma) and it is a marker for a variety of cell types in non-lymphoid tissues, including neurofibroma, ganglioneuroma and prostate carcinoma.

Literatur

[1] Ritchie AW, James K, Micklem HS (1983): The distribution and possible significance of cells identified in human lymphoid tissue by the monoclonal antibody HNK- 1. Clin Exp Immunol. 51(3):439-47.
[2] Abo T, Miller CA, Gartland GL and Balch CM (1983): Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life. J Exp Med. 157(1):273-84.
[3] Abo T and Balch CM (1981): A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol. 127(3):1024-9.
[4] Nielsen CM, White MJ, Goodier MR and Riley EM (2013): Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease. Front Immunol. 4:422.

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