Technische Daten
| Kontrolle: | Lesions of mastocytosis, small bowel | | Zelluläre Lokalisation: | Cytoplasmic, membranous | | Vorbehandlung: | ProTaqs® Antigen Enhancer IV (Cat. No. 401602392) | | Immunogen: | Synthetic peptide of human CD25 | | Ig Unterklasse: | IgG | | Spezies: | Rabbit | | Status: | In Vitro Diagnostic Use (IVD) | | Change(s) made: | Complete revision | | Synonyme: | Interleukin 2 receptor alpha chain, CD 25, CD25, CD25 antigen, IDDM10, IL 2 RA, IL 2 receptor alpha subunit, IL2 RA, IL2R, IL2RA, IL2RAC, Interleukin 2 Receptor Alpha, Interleukin 2 receptor alpha chain, Interleukin 2 receptor, Ly43, p55, T Cell Growth Factor Receptor, TAC Antigen, TCGFR. | | Verfügbar in folgenden Ländern: | worldwide |
Beschreibung
CD25, also known as IL2RA, is the alpha chain of interleukin 2 receptor. It is a type I transmembrane protein expressed on different cell types including activated T and B cells, some thymocytes, macrophages, myeloid precursors, and oligodendrocytes.
Antibody CD25 may be helpful in detection of most B-cell neoplasms, mastocytosis, hairy cell leukemia and chronic inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.
Literatur
[1] Dong HY, Weisberger J, Liu Z and Tugulea S (2009): Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. Am J Clin Pathol. 131(4):586-95.
[2] Pardanani A (2015): Systemic mastocytosis in adults: 2015 update on diagnosis, risk stratification, and management. Am J Hematol. 90(3):250-62.
[3] Choy MY, Walker-Smith JA, Williams CB and MacDonald TT (1990): Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut. 31(12):1365-70.
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