Technische Daten
Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | Kontrolle: | Lesions of mastocytosis, small bowel | Zelluläre Lokalisation: | Cytoplasmic, membranous | Fixierung: | 1) NOTOXhisto 2) Formalin | Anwendung AK: | IHC(p),IHC(f) | Immunogen: | Synthetic peptide of human CD25 | Ig Unterklasse: | IgG | Spezies: | Rabbit | Klon: | Polyclonal | Format AK: | Ready-to-use | Reaktivität AK: | Human, others not tested. | Synonyme: | Interleukin 2 receptor alpha chain, CD 25, CD25, CD25 antigen, IDDM10, IL 2 RA, IL 2 receptor alpha subunit, IL2 RA, IL2R, IL2RA, IL2RAC, Interleukin 2 Receptor Alpha, Interleukin 2 receptor alpha chain, Interleukin 2 receptor, Ly43, p55, T Cell Growth Factor Receptor, TAC Antigen, TCGFR. | Verfügbar in folgenden Ländern: | world wide (except US) | Status: | IVD |
Beschreibung
CD25 (Cluster of Differentiation 25) is a low-affinity receptor for interleukin-2 (IL-2). It is found on activated B-cells, T-cells, some thymocytes, myeloid precursors and oligodendrocytes. This antibody has been used to distinguish between neoplastic mast cell aggregates and reactive proliferations in Systemic Mastocytosis. It detects B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas and tumor infiltrating lymphocytes.
Literatur
[1] Dong HY, Weisberger J, Liu Z and Tugulea S (2009):
Immunophenotypic analysis of CD103+ Blymphoproliferative
disorders: hairy cell leukemia and its
mimics. Am J Clin Pathol. 131(4):586-95.
[2] Pardanani A (2015): Systemic mastocytosis in adults:
2015 update on diagnosis, risk stratification, and
management. Am J Hematol. 90(3):250-62.
[3] Choy MY, Walker-Smith JA, Williams CB and
MacDonald TT (1990): Differential expression of CD25
(interleukin-2 receptor) on lamina propria T cells and
macrophages in the intestinal lesions in Crohn's disease
and ulcerative colitis. Gut. 31(12):1365-70.
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