Technische Daten
| Kontrolle: | Tonsil, lymph node | | Zelluläre Lokalisation: | Membranous | | Vorbehandlung: | ProTaqs® Antigen Enhancer I (Cat. No. 401602092) | | Immunogen: | Synthetic peptide of human CD23 | | Ig Unterklasse: | IgG | | Spezies: | Rabbit | | Status: | In Vitro Diagnostic Use (IVD) | | Change(s) made: | Complete revision | | Synonyme: | Blast 2, Blast2, C type lectin domain family 4 member J, C-type lectin domain family 4, member J, CD 23, CD 23A, CD23 antigen, CD23A, CLEC 4J, CLEC4J, Fc epsilon RII, Fc fragment of IgE low affinity II receptor for, Fc fragment of IgE, low affinity II, receptor for (CD23), Fc of IgE, low affinity II, receptor for (CD23), Fc receptor IgE low affinity II alpha polypeptide, Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a, FCE 2, FCE2, FCER 2, FCER2, FCER2A, IgE binding factor, IgE receptor lymphocyte, IgE-binding factor, IGEBF, Immunoglobulin E binding factor, Immunoglobulin E receptor, low affinity II, Low affinity immunoglobulin epsilon Fc receptor, Low affinity immunoglobulin epsilon Fc receptor membrane bound form, Low affinity immunoglobulin epsilon Fc receptor soluble form, Ly-42, Ly42, Lymphocyte antigen CD23, Lymphocyte IgE receptor, MGC93219. | | Verfügbar in folgenden Ländern: | worldwide |
Beschreibung
CD23 is a type II transmembrane glycoprotein involved in B cell activation, B cell growth and regulation of IgE levels. Expression is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells and thrombocytes.
Antibody CD23 may be helpful in detection of B cell chronic lymphocytic leukemia (CLL), follicular dendritic cell tumors, mediastinal large B cell lymphoma and mantle cell lymphoma.
Literatur
[1] Acharya M, Borland G, Edkins AL et al. (2010): CD23/Fc_RII: molecular multi-tasking. Clin Exp Immunol. 162(1):12-23.
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