CD20cy B Cell

BLA36, Ms, 1 ml RTU

Artikelnummer:2-CD091-07
Menge:
Technische Daten
Reaktivität AK:Human, Cat, Dog, others not tested
Format AK:Ready-to-use
Klon:BLA36
Spezies:Mouse
Ig Unterklasse:IgG3
Immunogen:Hodgkin«s cell line (HDLM-3)
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Tonsil, lymph node
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:B-lymphocyte antigen CD20, MS4A1, B1, S7, BP35, LEU-16; MGC3969, B-lymphocyte cell-surface antigen B1
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

CD20 recognizes a glycoprotein of 36 kDa and is expressed on the surface of all B-cells. It is involved in B-cell activation, proliferation and differentiation and therefore one of the most important B-cell markers. Positive cells exhibit a cytoplasmic staining. On tonsils and hyperplastic lymph nodes BLA 36 stains centrocytes and to a lesser degree centrocytes in the germinal centers. In the mantle zone 30 to 60 % of the B-cells are stained as well as interdigitating reticulum cells. BLA 36 reacts with all HD subtypes, including Sternberg-Reed cells, Hodgkin cells and variants. In Non-Hodgkin lymphomas the majority of B-cell lineage lymphomas is detected.

Literatur

Jarig Darbs/ Monir Majzoub/ Walter Hermanns: Evaluation of the cross-reactivity between human and feline or canine leucocyte antigens using commercially available antibodies. In: J Vet Diagn Invest 9:94-97 (1997), S. 94-97.

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