Technische Daten
Kontrolle:Human tonsil
Zelluläre Lokalisation:Membranous
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Immunogen:Synthetic peptide of human CD205
Ig Unterklasse:IgG
Status:Research Use Only (RUO)
Change(s) made:Complete revision
Synonyme:Lymphocyte antigen 75, LY75, CD205, CLEC13B, DEC-205, GP200-MR6, CD 205, CD205 antigen, CLEC 13B, CLEC13B, gp200, LY 75, LY75, Lymphocyte antigen 75, Podocalyxin, Renal Cell Carcinoma (gp200), C type lectin domain family 13 member B
Verfügbar in folgenden Ländern:worldwide

Calcium-dependent (C-type) lectins are a family of lectins which share structural homology in their high-affinity carbohydrate-binding domain. Proteins of the CLEC superfamily function in a variety of biological processes, inclusing cell adhesion, cell-cell signalling, glycoprotein turnover, apoptosis, inflammation, and immune response to pathogens. CLEC13B/LY-75 is an endocytic receptor that directa captured antigens from the extracellular space to a specialized antigen-processing compartment. It reduces proliferation of B-lymphocytes. Expression is found in spleen, thymus, colon, and peripheral blood lymphocytes, in myeloid and B lymphoid cell lines, and isoforms 2 and 3 are detected in malignant Hodgkin lymphoma cells including Hodgkin and Reed-Sternberg cells.