CD20

L26, Ms

Artikelnummer:CD085-H
Menge:
Technische Daten
Kontrolle:Tonsil, lymph node
Zelluläre Lokalisation:Membranous
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Immunogen:CD20
Ig Unterklasse:IgG2a/k
Spezies:Mouse
Status:In Vitro Diagnostic Use (IVD)
Change(s) made:Complete revision
Synonyme:B-lymphocyte antigen CD20, MS4A1, B1, S7, BP35, LEU-16; MGC3969, B-lymphocyte cell-surface antigen B1
Verfügbar in folgenden Ländern:worldwide
Beschreibung

CD20 is a transmembrane phosphoprotein that functions as a calcium channel and participates in B cell activation, proliferation and differentiation. Expression is found on normal and malignant B cells, but not on plasma cells.
Antibody CD20 is a major marker for B cells and B cell derived neoplasms. CD20 may be helpful in detection of different B cell lymphoma, including lymphoblastic lymphoma/leukemia and diffuse large B cell lymphoma, as well as Reed-Sternberg cells in Hodgkin lymphoma.

Literatur

[1] Chu PG, Loera S, Huang Q and Weiss LM (2006): Lineage Determination of CD20Ð B-Cell Neoplasms. An Immunohistochemical Study. Am J Clin Pathol. 126:534-44.
[2] Selva RL, Violetti SA, Delfino C et al. (2017): A Literature Revision in Primary Cutaneous B-cell Lymphoma. Indian J Dermatol. 62(2):146-57.
[3] Benharroch D, Nalbandyan K and Lazarev I (2015): CD20 Over-Expression in Hodgkin-Reed-Sternberg Cells of Classical Hodgkin Lymphoma: the Neglected Quest. J Cancer. 6(11):1155-9.

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