Technische Daten
| Kontrolle: | Hodgkin's lymphoma | | Zelluläre Lokalisation: | Cytoplasmic, membranous | | Vorbehandlung: | ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392) | | Immunogen: | CD15 | | Ig Unterklasse: | IgM | | Spezies: | Mouse | | Status: | In Vitro Diagnostic Use (IVD) | | Change(s) made: | Complete revision | | Synonyme: | 3-fucosyl-N-acetyl-lactosamine, Lewis x, SSEA-1 | | Verfügbar in folgenden Ländern: | worldwide |
Beschreibung
CD15 (Cluster of Differentiation 15) is a carbohydrate adhesion molecule (not a protein) that can be expressed on glycoproteins, glycolipids and proteoglycans and that mediates phagocytosis and chemotaxis. This antibody detects Hodgkin's lymphoma, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias and most acute non-lymphocytic leukemias. It is a useful marker to distinguish between epithelial mesothelioma and adenocarcinoma.
Literatur
[1] Angel CA, Warford A, Day SJ & Lauder I (1989): Comparative quality assessment in immunocytochemistry: pilot study of CD15 staining in paraffin wax embedded tissue in Hodgkin's disease. J Clin Pathol. 42(10): 1096-100.
[2] Nakayama F, Nishihara S, Iwasaki H, et al. (2001): CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem. 276(19): 16100-6.
[3] Pinkus GS, Thomas P & Said JW (1985): Leu-M1--a marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues. Am J Pathol. 119(2): 244-52.
[4] Stein H, Gerdes J, Schwab U, et al. (1982): Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population. Int J Cancer. 30(4): 445-59.
[5] Stein H, Uch‡nska-Ziegler B, Gerdes J, et al. (1982): Hodgkin and Sternberg-Reed cells contain antigens specific to late cells of granulopoiesis. Int J Cancer. 29(3): 283-90.
[6] Stein H, Gerdes J, Schwab U, et al. (1983): Evidence for the detection of the normal counterpart of Hodgkin and Sternberg-Reed cells. Hematol Oncol. 1(1): 21-9.
[7] Stein H, Gerdes J, Schwab U, et al. (1983): Evidence for the origin of Hodgkin and Sternberg-Reed cells from a newly detected small cell population. Haematol Blood Transfus. 28: 407-10.
[8] Guzman J, Bross KJ & Costabel U (1991): Malignant lymphoma in pleural effusions: an immunocytochemical cell surface analysis. Diagn Cytopathol. 7(2): 113-8.
[9] Niedieck B & Löhler J (1987): Expression of 3-fucosyl-N-acetyllactosamine on glia cells and its putative role in cell adhesion. Acta Neuropathol. 75(2): 173-84.
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