CD14 (Cluster of Differentiation 14) is a glycosylphosphatidylinositol (GPI)-anchored surface protein preferentially expressed on monocytes and macrophages as well as a soluble protein in blood. This antibody detects lipopolysaccharide binding protein, apoptotic cells, Kupffer cells in liver sinusoids, dendritic cells in lymphoid tissues, monocyte-macrophages, Langerhans cells in Langerhans cell histiocytosis, tumor cells in monocytic leukemia and histiocytic lymphomas and numerous diffuse large B-cell lymphomas and splenic marginal zone lymphoma.