CD117/c-kit
Rb, 0.5 ml Conc.
Technische Daten
Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | Kontrolle: | Breast, GIST, skin, testes | Zelluläre Lokalisation: | Cytoplasmic, membranous | Fixierung: | 1) NOTOXhisto 2) Formalin | Anwendung AK: | IHC(p),IHC(f) | Immunogen: | Synthetic peptide of human CD117 C-terminal | Ig Unterklasse: | IgG | Spezies: | Rabbit | Klon: | Polyclonal | Format AK: | Concentrate | Reaktivität AK: | Human, others not tested. | Synonyme: | C Kit, CD 117, CD117, CD117 antigen, KIT, Mast/stem cell growth factor receptor, PBT, Proto oncogene tyrosine protein kinase Kit, Tyrosine-protein kinase Kit, SCF Receptor, SCFR, Stem cell factor receptor, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog, Bs, c-KIT, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W. | Verfügbar in folgenden Ländern: | world wide (except US) | Status: | IVD |
Beschreibung
CD117 (Cluster of Differentiation 117) is a tyrosine kinase receptor found on interstitial cells of germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid as well as adenocarcinomas from endometrium, lung, ovary, pancreas and breast, malignant melanoma, endodermal sinus tumor and small cell carcinoma.
Literatur
[1] Abbaspour Babaei M, Kamalidehghan B, Saleem M et
al. (2016): Receptor tyrosine kinase (c-Kit) inhibitors: a
potential therapeutic target in cancer cells. Drug Des
Devel Ther. 10:2443-59.
[2] Zhao F, Chen Y, Wu Q et al. (2014): Prognostic value
of CD117 in cancer: a meta-analysis. Int J Clin Exp
Pathol. 7(3):1012-21.
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