CD117/c-kit

Rb, 1 ml RTU

Artikelnummer:2-CD316-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Breast, GIST, skin, testes
Zelluläre Lokalisation:Cytoplasmic, membranous
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human CD117 C-terminal
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Ready-to-use
Reaktivität AK:Human, others not tested.
Synonyme:C Kit, CD 117, CD117, CD117 antigen, KIT, Mast/stem cell growth factor receptor, PBT, Proto oncogene tyrosine protein kinase Kit, Tyrosine-protein kinase Kit, SCF Receptor, SCFR, Stem cell factor receptor, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog, Bs, c-KIT, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CD117 (Cluster of Differentiation 117) is a tyrosine kinase receptor found on interstitial cells of germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid as well as adenocarcinomas from endometrium, lung, ovary, pancreas and breast, malignant melanoma, endodermal sinus tumor and small cell carcinoma.

Literatur

[1] Abbaspour Babaei M, Kamalidehghan B, Saleem M et al. (2016): Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells. Drug Des Devel Ther. 10:2443-59.
[2] Zhao F, Chen Y, Wu Q et al. (2014): Prognostic value of CD117 in cancer: a meta-analysis. Int J Clin Exp Pathol. 7(3):1012-21.

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