CD103/Integrin alpha E

Rb, 0.5 ml Conc.

Artikelnummer:1-CD297-05
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Human colon tissue
Zelluläre Lokalisation:Membranous
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human CD103
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Concentrate
Reaktivität AK:Human, others not tested.
Synonyme:alpha-E1, alpha-M290, aM290, Antigen CD103, CD 103, CD103, CD103 antigen, HML 1 antigen, HML1 antigen, Human mucosal lymphocyte antigen 1, Human mucosal lymphocyte antigen 1, alpha subunit, Huminae, Integrin alpha E heavy chain, Integrin alpha E light chain, Integrin alpha E, epithelial-associated, Integrin alpha E1, Integrin alpha IEL, Integrin alpha M290, Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide), Integrin, alpha E, ITGAE, MGC141996, MGC183601, Mucosal lymphocyte 1 antigen, Mucosal lymphocyte antigen 1.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CD103, also known as integrin alpha E (ITGAE), is an integrin protein that binds to integrin beta 7 and mediates cell adhesion, migration and signaling. Furthermore, it is important for T lymphocyte localization. CD103 is expressed on intraepithelial lymphocytes in mucosal areas, including lung and GI tract. In malignancies, it is present on all enteropathy-type T-cell lymphomas and has been useful as a marker for hairy cell leukemia.

Literatur

[1] Anz D, Mueller W, Golic M et al. (2011): CD103 is a hallmark of tumor-infiltrating regulatory T cells. Int J Cancer. 129(10):2417-26.
[2] Uss E, Rowshani AT, Hooibrink B et al. (2006): CD103 is a marker for alloantigen-induced regulatory CD8+ T cells. J Immunol. 177(5):2775-83.
[3] Venkataraman G, Aguhar C, Kreitman RJ et al. (2011): Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia: usefulness of CD123 and CD103 in the diagnosis of mature B-cell lymphoproliferative disorders. Am J Clin Pathol. 136(4):625-30.

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