Bcl6 - Format: 7 ml

GI191E/A8, Ms, 7 ml RTU

Technische Daten
Kontrolle:Tonsil, lymph node
Zelluläre Lokalisation:Nuclear
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Immunogen:BCL6 protein
Ig Unterklasse:IgG1
Status:Research Use Only (RUO)
Change(s) made:Complete revision
Synonyme:B cell lymphoma 6/Bcl6
Verfügbar in folgenden Ländern:worldwide

Bcl-6 is a regulatory gene encoding a zinc finger protein. It plays a key role in the formation of the germinal center (GC) and acts as a regulator of B lymphocyte growth and development by protecting GC-B cells from DNA damage-induced apoptosis. Bcl-6 is mainly expressed in GC-B cells. Surrounding mantle-zone and marginal-zone B cells, plasma cells, and progenitor B cells are negative for Bcl-6. The antibody Bcl-6 detects GC cells in lymphoid follicles and a variety of lymphomas including follicular lymphomas, diffuse large B-cell lymphomas (DLBCL) and BurkittÍs lymphomas. In contrast, Bcl-6 is not expressed in hairy cell leukemias, mantle cell or peripheral lymphomas. Bcl-6 is not restricted to the B cell line, but could also be detected in anaplastic large cell lymphoma. Furthermore, Bcl-6 is involved in mammary epithelial differentiation, which could play a potential role in carcinogenesis.


[1] Falini B, Fizzotti M, Pileri S et al. (1997): Bcl-6 protein expression in normal and neoplastic lymphoid tissues. Ann Oncol. 8 Suppl 2:101-4.
[2] Logarajah S, Hunter P, Kraman M et al. (2003): BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation. Oncogene. 22(36):5572-8.
[3] Duy C, Yu JJ, Nahar R et al. (2010): BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med. 207(6):1209-21.
[4] Dogan A, Bagdi E, Munson P and Isaacson PG (2000): CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg Pathol. 24(6):846-52.
[5] Saglam A and Uner AH (2011): Immunohistochemical expression of Mum-1, Oct-2 and Bcl-6 in systemic anaplastic large cell lymphomas. Tumori. 97(5):634-8.
[6] Ye BH, Rao PH, Chaganti RS and Dalla-Favera R (1993): Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res. 53(12):2732-5.
[7] Garc’a JF, Garc’a JF, Maestre L et al. (2006): Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections. J Histochem Cytochem. 54(1):31-8.