B cell lymphoma 6/Bcl6

GI191E/A8, Ms, 1 ml RTU

Artikelnummer:2-B0015-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:GI191E/A8
Spezies:Mouse
Ig Unterklasse:IgG1
Immunogen:BCL6 protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Nuclear
Kontrolle:Tonsil, lymph node
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:BCL6
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

This antibody recognizes the regulator gene BCL6, which encodes for a zinc finger protein. It detects germinal center cells in lymphoid follicles and a variety of lymphomas including Burkitt's lymphoma and nodular lymphocyte predominant Hodgkin's Disease. BCL6 is not expressed in hairy cell leukemia, mantle cell or marginal-zone derived lymphomas.

Literatur

[1] Falini B, Fizzotti M, Pileri S et al. (1997): Bcl-6 protein expression in normal and neoplastic lymphoid tissues. Ann Oncol. 8 Suppl 2:101-4.
[2] Logarajah S, Hunter P, Kraman M et al. (2003): BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation. Oncogene. 22(36):5572-8.
[3] Duy C, Yu JJ, Nahar R et al. (2010): BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med. 207(6):1209-21.
[4] Dogan A, Bagdi E, Munson P and Isaacson PG (2000): CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg Pathol. 24(6):846-52.
[5] Saglam A and Uner AH (2011): Immunohistochemical expression of Mum-1, Oct-2 and Bcl-6 in systemic anaplastic large cell lymphomas. Tumori. 97(5):634-8.
[6] Ye BH, Rao PH, Chaganti RS and Dalla-Favera R (1993): Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res. 53(12):2732-5.
[7] Garc’a JF, Garc’a JF, Maestre L et al. (2006): Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections. J Histochem Cytochem. 54(1):31-8.

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