B cell lymphoma 6/Bcl6
GI191E/A8, Ms, 1 ml RTU
Technische Daten
| Reaktivität AK: | Human, others not tested. | | Format AK: | Ready-to-use | | Klon: | GI191E/A8 | | Spezies: | Mouse | | Ig Unterklasse: | IgG1 | | Immunogen: | BCL6 protein | | Anwendung AK: | IHC(p),IHC(f) | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Zelluläre Lokalisation: | Nuclear | | Kontrolle: | Tonsil, lymph node | | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Synonyme: | BCL6 | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
This antibody recognizes the regulator gene BCL6, which encodes for a zinc finger protein. It detects germinal center cells in lymphoid follicles and a variety of lymphomas including Burkitt's lymphoma and nodular lymphocyte predominant Hodgkin's Disease. BCL6 is not expressed in hairy cell leukemia, mantle cell or marginal-zone derived lymphomas.
Literatur
[1] Falini B, Fizzotti M, Pileri S et al. (1997): Bcl-6 protein
expression in normal and neoplastic lymphoid tissues.
Ann Oncol. 8 Suppl 2:101-4.
[2] Logarajah S, Hunter P, Kraman M et al. (2003): BCL-6
is expressed in breast cancer and prevents mammary
epithelial differentiation. Oncogene. 22(36):5572-8.
[3] Duy C, Yu JJ, Nahar R et al. (2010): BCL6 is critical
for the development of a diverse primary B cell repertoire.
J Exp Med. 207(6):1209-21.
[4] Dogan A, Bagdi E, Munson P and Isaacson PG
(2000): CD10 and BCL-6 expression in paraffin sections
of normal lymphoid tissue and B-cell lymphomas. Am J
Surg Pathol. 24(6):846-52.
[5] Saglam A and Uner AH (2011): Immunohistochemical
expression of Mum-1, Oct-2 and Bcl-6 in systemic
anaplastic large cell lymphomas. Tumori. 97(5):634-8.
[6] Ye BH, Rao PH, Chaganti RS and Dalla-Favera R
(1993): Cloning of bcl-6, the locus involved in
chromosome translocations affecting band 3q27 in B-cell
lymphoma. Cancer Res. 53(12):2732-5.
[7] Garc’a JF, Garc’a JF, Maestre L et al. (2006): Genetic
immunization: a new monoclonal antibody for the
detection of BCL-6 protein in paraffin sections. J
Histochem Cytochem. 54(1):31-8.
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