Arginase-1

Rb

Artikelnummer:AR007-H
Menge:
Technische Daten
Kontrolle:Human hepatocellular carcinoma
Zelluläre Lokalisation:Cytoplasmic
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Immunogen:Synthetic peptide of human Arg-1
Ig Unterklasse:IgG
Spezies:Rabbit
Status:In Vitro Diagnostic Use (IVD)
Change(s) made:Complete revision
Synonyme:ARG 1, ARG1, ARGI1_HUMAN, Arginase1, Arginase liver, Arginase type I, Arginase I, ArginaseI, Arginase-1, Arginase1, Liver type arginase, Liver-type arginase, Type I arginase.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Arginase (ARG) is a manganese metalloenzyme that is part of the urea cycle. It catalyses the conversion of Larginine to L-ornithine and urea. ARG-1 and ARG-2 are the two isoforms of ARG. ARG-1 is a cytosolic enzyme expressed in liver. The ARG-1 antibody is a sensitive marker of hepatic differentiation and is useful in the detection of hepatocytes in normal tissue as well as granulocytes in peripheral blood. For the identification of hepatocellular carcinoma ARG-1 is a sensitive and specific marker.

Literatur

[1] Haraguchi Y, Takiguchi M, Amaya Y et al. (1987) Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc Natl Acad Sci U S A 84(2):412-5.
[2] de Boniface J, Mao Y, Schmidt-Mende J et al. (2012) Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients. Oncoimmunology 1(8):1305-1312.
[3] Fujiwara M1, Kwok S, Yano H et al. (2012) Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and glypican-3 in fine-needle aspiration biopsies. Cancer Cytopathol. 120(4):230-7.
[4] Radwan NA and Ahmed NS (2012) The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1. Diagn Pathol. 7:149.

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