p63

QR007, Rb

Artikelnummer:P004-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human p63 protein
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Prostate
Synonyme:AIS, Amplified in squamous cell carcinoma, B(p51A), B(p51B), p63 Alpha, Chronic ulcerative stomatitis protein, CUSP, DN p63 alpha 1, DNp63, EEC3, Keratinocyte transcription factor, Keratinocyte transcription factor KET, KET, LMS, NBP, OFC8, p40, p51, P51/P63, p53 like transcription factor, p53 related protein, p53-related protein p63, p53CP, p63, P73, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP63, TP73, TP73L, Transformation related protein 63, Trp53rp1, Trp63, Tumor protein 63, tumor protein 63 kDa with strong homology to p53, Tumor protein p53-competing protein, Tumor protein p53-like, tumor protein p63, Tumor protein p73, tumor protein p73-like
Verfügbar in folgenden Ländern:worldwide
Beschreibung

p63 is a transcription factor with significant structural similarity to p53 and p73. p63 plays a more fundamental role in development and differentiation and is detected in a variety of human tissues, including basal cells in the epidermis, urothelium and glandular epithelium.
The antibody p63 may be useful in the detection of squamous cell carcinoma of the head and neck or for the differentiation between prostate adenocarcinoma and benign prostate tissue.

Literatur

[1] Gonfloni S, Caputo V and Iannizzotto V (2015): P63 in health and cancer. Int J Dev Biol. 59(1-3):87-93.
[2] Yang A1, Kaghad M, Wang Y et al. (1998): p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 2(3):305-16.
[3] Shiran MS, Tan GC, Sabariah AR et al. (2007): p63 as a complimentary basal cell specific marker to high molecular weight-cytokeratin in distinguishing prostatic carcinoma from benign prostatic lesions. Med J Malaysia. 62(1):36-9.
[4] Schmale H and Bamberger C (1997): A novel protein with strong homology to the tumor suppressor p53. Oncogene. 15(11):1363-7.

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