p53

QR025, Rb

Artikelnummer:P011-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human p53
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Breast carcinoma, colon carcinoma
Synonyme:Antigen NY-CO-13, Cellular tumor antigen p53, FLJ92943, LFS1, p53 tumor suppressor, Phosphoprotein p53, TP53, Transformation related protein 53, TRP53, Tumor protein p53, Tumor suppressor p53
Verfügbar in folgenden Ländern:worldwide
Beschreibung

p53 is a tumor suppressor gene and transcription factor. Due to DNA mutations and other cell stress signals p53 helps to start transcription of genes that trigger cell cycle arrest, apoptosis and DNA repair. Mutations in p53 gene lead to loss of tumor suppressor function. In normal cells p53 exists at very low almost undetectable levels as it has a short half-life period. In malignant cells p53 is overexpressed and shows a greatly increased half-life. Overexpression is found in more than 50 % of human cancers and may be associated with aggressive progression and poor prognosis. Antibody p53 may be helpful in detection of carcinomas of colon, breast, lung, prostate and ovary.

Literatur

[1] Lakin ND and Jackson SP (1999): Regulation of p53 in response to DNA damage. Oncogene. 18(53):7644-55.
[2] Levine AJ (1997): p53, the cellular gatekeeper for growth and division. Cell. 88(3):323-31.

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