p40

QR020, Rb

Artikelnummer:P007-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human p40
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Lung, lung squamous cell carcinoma
Synonyme:RABEPK, RAB9P40, bA65N13.1, p40, Rab9 effector protein with kelch motifs
Verfügbar in folgenden Ländern:worldwide
Beschreibung

p40, also known as deltaNp63, is an isoform of TP63 that lacks the transactivation domain. p40 is expressed in the nucleus of the normal breast myoepithelium and in the epidermal cells of the skin. In tumor tissues p40 staining is observed in lung and cervical squamous cell carcinoma.
p40 antibody recognizes the shortest variant of human p53 and can be a valuable marker in cases where p63 has been used traditionally. The transcription factor p63 was identified as a p53 homolog. p63 is currently the most commonly used marker for squamous cell carcinoma of the lung (SqCC). In a recent study, the p40 staining was equivalent to the sensitivity to SqCC of p63, but was significantly better specific than p63. This report strongly supports the routine use of p40 as an alternative to p63 in the diagnosis of pulmonary squamous cell carcinoma. p40 can prove to be an important antibody in the differential diagnosis of lung adenocarcinoma against lung SqCC.

Literatur

[1] Bishop JA, Teruya-Feldstein J, Westra WH et al. (2012): p40 (_Np63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 25(3):405-15.
[2] Nobre AR, Albergaria A and Schmitt F (2013): p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta Cytol. 57(1):1-8.
[3] Ao MH, Zhang H1, Sakowski L et al. (2014): The utility of a novel triple marker (combination of TTF1, napsin A, and p40) in the subclassification of non-small cell lung cancer. Hum Pathol. 45(5):926-34.
[4] Parsons CLM, Tucker HLM, Akers RM and Daniels KM (2018): Technical note: p40 antibody as a replacement for p63 antibody in bovine mammary immunohistochemistry. J Dairy Sci.101(8):7614-7617.
[5] Reddy AB, Chatterjee A, Rothblum L et al. (1989): Isolation and characterization of complementary DNA to proliferating cell nucleolar antigen P40. Cancer Res. 49(7):1763-7.
[6] Hagiwara K, McMenamin MG, Miura K and Harris CC (1999): Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers. Cancer Res. 59(17):4165-9.

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