S100

QR031, Rb

Artikelnummer:S003-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human S100
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Melanoma
Synonyme:Bpb, NEF, Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 alpha, S100 beta, S100 calcium binding protein A1, S100 calcium binding protein B, S100 calcium-binding protein A1, S100 protein alpha polypeptide, S100A, s100a1, S100B, S100beta, S10A1_HUMAN
Verfügbar in folgenden Ländern:worldwide
Beschreibung

S100 belongs to the family of calcium binding proteins. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chrondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. This antibody detects neoplasms derived from these cells, a large number of tumors of the salivary gland, adipose and cartilaginous tissue, Schwann cell derived tumors, and almost all malignant melanomas and cases of histiocytosis x.

Literatur

[1] Donato R (1999): Functional roles of S100 betas, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta. 1450(3):191-231.
[2] Clarkson KS, Sturdgess IC and Molyneux AJ (2001): The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB45, and A103 (anti-melan-A). J Clin Pathol. 54(3):196-200.
[3] Smith SP and Shaw GS (1998): A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. Structure. 6(2):211-22.
[4] HydŽn H, Lange PW (1970): S100 brain protein: correlation with behavior. Proc Natl Acad Sci U S A. 67(4):1959-66.

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