Progesterone receptor

QR014, Rb

Artikelnummer:P006-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human progesterone receptor
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Nuclear
Kontrolle:Breast, breast cancer
Synonyme:NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor, Progestin receptor form A, Progestin receptor form B.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

PR is a nuclear hormone receptor that activates transcription of various genes, especially in reproductive tissues, regulated by its ligand progesterone. Two isoforms exist : PR-A (94 kDa) and PR-B (114 kDa). Antibody PR detects both isoforms. Ratio of these isoforms varies in reproductive tissues and during carcinogenesis. The antibody labels cells in breast, ovary and uterus, and is an important marker for detection of breast cancer.

Literatur

[1] Mulac-Jericevic B, Conneely OM (2004): Reproductive tissue selective actions of progesterone receptors. Reproduction. 128(2): 139-146.
[2] Duffy MJ, Harbeck N, Nap M et al. (2017): Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM). Eur J Cancer. 75: 284-298.
[3] Schettini F, Buono G, Cardalesi C et al. (2016): Hormone Receptor/Human Epidermal Growth Factor Receptor 2-positive breast cancer: Where we are now and where we are going. Cancer Treat Rev. 46: 20-26.
[4] Wei LL, Miner R (1994): Evidence for the existence of a third progesterone receptor protein in human breast cancer cell line T47D. Cancer Res. 54(2): 340-343.

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